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Research Studies is a compilation of published research articles funded by 大象APPor authored by 大象APPresearchers.

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1 to 2 of 2 Research Studies Displayed
Liu Y, Rothenberger SD, Tadrous M
Trends in opioid and gabapentinoid utilization: a time-series analysis across 72 countries from 2012 to 2023.
This study鈥檚 objective was to compare global trends in gabapentinoid and opioid utilization overall and by economic development category, and also to predict future trends. Global gabapentinoid annual sales rose by an average of 114.5% from 2012 to 2022, with a higher increase in developing (180.9%) than developed economies (110.0%). By contrast, annual opioid sales declined globally by 25.4%, with a 27.9% decrease in developed and a 16.8% increase in developing economies. Predicting future trends if current ones persist over the following 3 years, gabapentinoid quarterly sales are forecasted to rise by 7.7% in developed and 18.6% in developing economies, while opioid quarterly sales are expected to decrease by 9.5% and increase by 15.1%, respectively. Using Granger causality tests, gabapentinoids may predict opioid sales globally for the following year, but opioids did not predict gabapentinoid sales.
AHRQ-funded; HS027985.
Citation: Liu Y, Rothenberger SD, Tadrous M . Trends in opioid and gabapentinoid utilization: a time-series analysis across 72 countries from 2012 to 2023. Pharmacoepidemiol Drug Saf 2025 May; 34(5):e70149. doi: 10.1002/pds.70149.
Keywords: Opioids, Medication, Practice Patterns
Antoon JW, Nian H, Todd J
Guideline-concordant antibiotic use in children with community-acquired pneumonia.
Although national guidelines recommend narrow-spectrum antibiotics for pediatric pneumonia, adherence remains inconsistent. This retrospective study of children treated at two emergency departments found that just 57% of those receiving antibiotics were treated in accordance with guidelines. Factors associated with better adherence included chest indrawing, while interstitial findings and lack of viral testing were linked to guideline-discordant prescribing. The findings suggest that more targeted antimicrobial stewardship interventions are needed in pediatric emergency settings to promote evidence-based prescribing and reduce unnecessary broad-spectrum antibiotic use.
AHRQ-funded; HS029331.
Citation: Antoon JW, Nian H, Todd J . Guideline-concordant antibiotic use in children with community-acquired pneumonia. Hosp Pediatr 2025 Apr; 15(4):300-08. doi: 10.1542/hpeds.2024-007994..
Keywords: Children/Adolescents, Antibiotics, Pneumonia, Respiratory Conditions, Community-Acquired Infections, Antimicrobial Stewardship, Guidelines, Practice Patterns

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